The current ICE age: Biology and evolution of SXT-related integrating conjugative elements

被引：164

作者：

Burrus, V

Marrero, J

Waldor, MK ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[2] Howard Hughes Med Inst, Boston, MA 02111 USA

来源：

PLASMID | 2006年 / 55卷 / 03期

关键词：

integrating conjugative element; ICE; Vibrio cholerae; gamma-proteobacteria; SXT; R391; antibiotic resistance;

D O I：

10.1016/j.plasmid.2006.01.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

SXT is an integrating Conjugative element (ICE) that was initially isolated from a 1992 Vibrio cholerae 0 139 clinical isolate from India. This similar to 100-kb ICE encodes resistance to multiple antibiotics. SXT or closely related ICEs are now present in most clinical and some environmental V. cholerae isolates from Asia and Africa. SXT-related ICEs are not limited to V. cholerae. It is now clear that so-called IncJ elements such its R391 are closely related to SXT. More than 25 members of the SXT/R391 family of ICEs have now been identified in environmental and clinical isolates of diverse species of gamma-proteobacteria worldwide. In this review, we discuss the diversity, evolution and biology of this family of ICEs. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：173 / 183

页数：11

共 45 条

[1] A variant type of Vibrio cholerae SXT element in a multidrug-resistant strain of Vibrio fluvialis [J].