What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

被引：97

作者：

Stopper, Colin M.

Floresco, Stan B. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 01期

基金：

加拿大健康研究院;

关键词：

ROSTROMEDIAL TEGMENTAL NUCLEUS; MIDBRAIN DOPAMINE NEURONS; DEEP BRAIN-STIMULATION; REWARD; DEPRESSION; SIGNALS; AREA;

D O I：

10.1038/nn.3587

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lateral habenula (LHb) is believed to convey an aversive or 'anti-reward' signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger or smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily conserved LHb acts as a preference center that is integral for expressing subjective decision biases.

引用

收藏

页码：33 / 35

页数：3

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