The p24 family of transmembrane proteins at the interface between endoplasmic reticulum and Golgi apparatus

被引：19

作者：

Emery, G ^{[1
]}

Gruenberg, J ^{[1
]}

Rojo, M ^{[1
]}

机构：

[1] Univ Geneva, Dept Biochim, Geneva, Switzerland

来源：

PROTOPLASMA | 1999年 / 207卷 / 1-2期

关键词：

p24; family; membrane traffic; transmembrane protein; protein sorting; protein transport; coat protein;

D O I：

10.1007/BF01294710

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The p24 family of small transmembrane proteins was discovered recently in yeast and mammalian cells, and some of its members have been implicated in biosynthetic protein transport. The p24 proteins are proposed to act on transport vesicles as receptors for coat and/or cargo, but their precise function(s) remain controversial. Here, we describe this protein family, and we review the available experimental data concerning their localization and function. Finally, we hypothesize about a possible role of p24 proteins in organelle morphogenesis.

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页码：24 / 30

页数：7

相关论文

共 30 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[2] Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport [J].

Belden, WJ ;

Barlowe, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (43) :26939-26946

[3] Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking [J].

Blum, R ;

Feick, P ;

Puype, M ;

Vandekerckhove, J ;

Klengel, R ;

Nastainczyk, W ;

Schulz, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (29) :17183-17189

[4] Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].

不详 .

SCIENCE, 1998, 282 (5396) :2012-2018

[5] Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting [J].

Cosson, P ;

Letourneur, F .

CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (04) :484-487

[6] gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer [J].

Dominguez, M ;

Dejgaard, K ;

Füllekrug, J ;

Dahan, S ;

Fazel, A ;

Paccaud, JP ;

Thomas, DY ;

Bergeron, JJM ;

Nilsson, T .

JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :751-765

[7] Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations [J].

ElrodErickson, MJ ;

Kaiser, CA .

MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (07) :1043-1058

[8] IDENTIFYING NONPOLAR TRANSBILAYER HELICES IN AMINO-ACID-SEQUENCES OF MEMBRANE-PROTEINS [J].

ENGELMAN, DM ;

STEITZ, TA ;

GOLDMAN, A .

ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1986, 15 :321-353

[9] Sorting determinants in the transmembrane domain of p24 proteins [J].

Fiedler, K ;

Rothman, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) :24739-24742

[10] Bimodal interaction of coatomer with the p24 family of putative cargo receptors [J].

Fiedler, K ;

Veit, M ;

Stamnes, MA ;

Rothman, JE .

SCIENCE, 1996, 273 (5280) :1396-1399