Transient lesion in the splenium related to antiepileptic drug: Case report and new pathophysiological insights

被引：30

作者：

Anneken, Kerstin ^{[1
]}

Evers, Stefan ^{[1
]}

Mohammadi, Siawoosh ^{[1
]}

Schwindt, Wolfram ^{[2
]}

Deppe, Michael ^{[1
]}

机构：

[1] Univ Munster, Dept Neurol, D-48149 Munster, Germany

[2] Univ Munster, Dept Clin Radiol, D-48149 Munster, Germany

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2008年 / 17卷 / 07期

关键词：

Antiepileptic drug treatment; Transient lesion of the splenium; Diffusion tensor imaging; Cytotoxic oedema;

D O I：

10.1016/j.seizure.2008.01.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transient focal lesions in the splenium of the corpus callosum (SCC) have been associated with antiepileptic drug (AED) treatment. However, the aetiology is widely unknown. We describe a transient SCC lesion in an epilepsy patient after abrupt AED reduction. Whole head high-field diffusion tensor imaging (DTI) including fully automated quantitative fractional anisotropy (FA) analysis was used to get insight into the pathophysiology of transient SCC lesions. Our results demonstrate that a reversible toss of directional fibre organisation in the splenium, likely due to intramyelinic oedema, is the morphological correlate of transient SCC lesions. We conclude that DTI provides a highly sensitive and quantitative tool. to detect subtle and transient loss of fibre integrity associated with AED treatment. (C) 2008 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：654 / 657

页数：4

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