Stem cells: hype or hope?

被引：17

作者：

Paul, G ^{[1
]}

Li, JY ^{[1
]}

Brundin, P ^{[1
]}

机构：

[1] Lund Univ, Wallenberg Neurosci Ctr, Sect Neuronal Survival, S-22184 Lund, Sweden

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 05期

关键词：

D O I：

10.1016/S1359-6446(01)02155-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stem cells undergo self-renewal and differentiate into multiple lineages of mature cells. The identification of stem cells in diverse adult tissues and the findings that human embryonic stem cells can be proliferated and differentiated has kindled the imagination of both scientists and the public regarding future stem cell technology. These cells could constitute an unlimited supply of diverse cell types that can be used for cell transplantation or drug discovery. The new options raise several fundamental ethical issues. This review gives an overview of the scientific basis underlying the hope generated by stem cell research and discusses current ethical and funding regulations.

引用

页码：295 / 302

页数：8

共 80 条

[1] Cell differentiation - Hepatocytes from nonhepatic adult stem cells [J].

Alison, MR ;

Poulsom, R ;

Jeffery, R ;

Dhillon, AP ;

Quaglia, A ;

Jacob, J ;

Novelli, M ;

Prentice, G ;

Williamson, J ;

Wright, NA .

NATURE, 2000, 406 (6793) :257-257

[2] Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture [J].

Amit, M ;

Carpenter, MK ;

Inokuma, MS ;

Chiu, CP ;

Harris, CP ;

Waknitz, MA ;

Itskovitz-Eldor, J ;

Thomson, JA .

DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :271-278

[3] A COMPARATIVE-STUDY OF 8 CELL-LINES DERIVED FROM HUMAN TESTICULAR TERATOCARCINOMA [J].

ANDREWS, PW ;

BRONSON, DL ;

BENHAM, F ;

STRICKLAND, S ;

KNOWLES, BB .

INTERNATIONAL JOURNAL OF CANCER, 1980, 26 (03) :269-280

[4]

ANDREWS PW, 1984, LAB INVEST, V50, P147

[5]

Antoniou M, 2001, NAT MED, V7, P397, DOI 10.1038/86444

[6] Insulin production by human embryonic stem cells [J].

Assady, S ;

Maor, G ;

Amit, M ;

Itskovitz-Eldor, J ;

Skorecki, KL ;

Tzukerman, M .

DIABETES, 2001, 50 (08) :1691-1697

[7] Type 1 diabetes: new perspectives on disease pathogenesis and treatment [J].

Atkinson, MA ;

Eisenbarth, GS .

LANCET, 2001, 358 (9277) :221-229

[8] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].

Azizi, SA ;

Stokes, D ;

Augelli, BJ ;

DiGirolamo, C ;

Prockop, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3908-3913

[9] EMBRYONIC STEM-CELLS EXPRESS NEURONAL PROPERTIES IN-VITRO [J].

BAIN, G ;

KITCHENS, D ;

YAO, M ;

HUETTNER, JE ;

GOTTLIEB, DI .

DEVELOPMENTAL BIOLOGY, 1995, 168 (02) :342-357

[10] Embryonic stem cells and in vitro muscle development [J].

Baker, RK ;

Lyons, GE .

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 33, 1996, 33 :263-279

← 1 2 3 4 5 6 7 8 →