Incidence of diabetes mellitus in a population-based cohort of persons with chronic hepatitis B virus infection

被引：47

作者：

Spradling, P. R. ^{[1
]}

Simons, B. ^{[2
]}

Narayanan, M. ^{[3
]}

Xing, J. ^{[1
]}

Homan, C. ^{[2
]}

Bulkow, L. ^{[4
]}

Cagle, H. ^{[2
]}

Schraer, C. D. ^{[3
]}

McMahon, B. J. ^{[2
,4
]}

机构：

[1] Ctr Dis Control & Prevent CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA

[2] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA

[3] Alaska Native Diabet Program, Anchorage, AK USA

[4] Ctr Dis Control & Prevent CDC, Arctic Invest Program, Div Preparedness & Emerging Infect Dis, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA

来源：

JOURNAL OF VIRAL HEPATITIS | 2013年 / 20卷 / 07期

关键词：

diabetes; hepatitis B; incidence; liver disease; ASSOCIATION;

D O I：

10.1111/jvh.12071

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

To investigate the effect of hepatitis B virus (HBV) infection on the development of diabetes mellitus (DM), we compared DM incidence and characteristics of Alaska Native persons with and without HBV infection. From 1990 to 2010, there were 52 incident DM cases among 1309 persons with infection vs 4557 DM cases among 85698 persons without infection (log-rank test, P=0.20). Compared to infected persons without DM, those with DM were significantly older (57.0 vs 47.4years, P<0.001) and had higher body mass index (34.5 vs 28.4kg/m2, P<0.001). Genotype, immune active disease and the presence of cirrhosis were not associated with DM. In this population-based cohort with over 20years of follow-up, there was no effect of HBV infection on DM development.

引用

页码：510 / 513

页数：4

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