Nematode ageing: Putting metabolic theories to the test

被引:31
作者
Gems, D [1 ]
机构
[1] Univ London Univ Coll, Dept Biol, London NW1 2HE, England
关键词
D O I
10.1016/S0960-9822(99)80387-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The increased life span caused by certain mutations in the nematode Caenorhabditis elegans has been interpreted in terms of two metabolic theories of ageing: the oxidative damage theory and the rate of living theory. New findings support the former, but not the latter interpretation.
引用
收藏
页码:R614 / R616
页数:3
相关论文
共 10 条
[1]   Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans [J].
Braeckman, BP ;
Houthoofd, K ;
De Vreese, A ;
Vanfleteren, JR .
CURRENT BIOLOGY, 1999, 9 (09) :493-496
[2]   Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1 [J].
Ewbank, JJ ;
Barnes, TM ;
Lakowski, B ;
Lussier, M ;
Bussey, H ;
Hekimi, S .
SCIENCE, 1997, 275 (5302) :980-983
[3]   CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans [J].
Felkai, S ;
Ewbank, JJ ;
Lemieux, J ;
Labbé, JC ;
Brown, GG ;
Hekimi, S .
EMBO JOURNAL, 1999, 18 (07) :1783-1792
[4]  
FRIEDMAN DB, 1988, GENETICS, V118, P75
[5]   The genetics of caloric restriction in Caenorhabditis elegans [J].
Lakowski, B ;
Hekimi, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13091-13096
[6]  
Murakami S, 1996, GENETICS, V143, P1207
[7]   Oxidative stress, caloric restriction, and aging [J].
Sohal, RS ;
Weindruch, R .
SCIENCE, 1996, 273 (5271) :59-63
[8]   RETRACTED: A cytosolic catalase is needed to extend adult lifespan in C-elegans daf-C and clk-1 mutants (Retracted Article. See, vol 421, pg 764, 2003) [J].
Taub, J ;
Lau, JF ;
Ma, C ;
Hahn, JH ;
Hoque, R ;
Rothblatt, J ;
Chalfie, M .
NATURE, 1999, 399 (6732) :162-166
[9]   OXIDATIVE STRESS AND AGING IN CAENORHABDITIS-ELEGANS [J].
VANFLETEREN, JR .
BIOCHEMICAL JOURNAL, 1993, 292 :605-608
[10]  
WONG A, 1995, GENETICS, V139, P1247