Role of ABC transporters in lipid transport and human disease

被引：232

作者：

Tarling, Elizabeth J. ^{[1
,2
]}

Vallim, Thomas Q. de Aguiar ^{[1
,2
]}

Edwards, Peter A. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 07期

关键词：

lipid transport; intracellular; ABC transporter; BINDING CASSETTE TRANSPORTER; X-LINKED ADRENOLEUKODYSTROPHY; INWARD-FACING CONFORMATION; MULTIDRUG-RESISTANCE GENE; CHOLESTEROL HOMEOSTASIS; PHOSPHOLIPID FLIPPASES; ALZHEIMERS-DISEASE; CRYSTAL-STRUCTURE; FLIP-FLOP; MICE;

D O I：

10.1016/j.tem.2013.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Almost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids. Mutations in a substantial number of the 48 human ABC transporters have been linked to human disease. Indeed the finding that 12 diseases have been associated with abnormal lipid transport and/or homeostasis demonstrates the importance of this family of transporters in cell physiology. This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders.

引用

页码：342 / 350

页数：9

共 68 条

[1] Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [J].

Aller, Stephen G. ;

Yu, Jodie ;

Ward, Andrew ;

Weng, Yue ;

Chittaboina, Srinivas ;

Zhuo, Rupeng ;

Harrell, Patina M. ;

Trinh, Yenphuong T. ;

Zhang, Qinghai ;

Urbatsch, Ina L. ;

Chang, Geoffrey .

SCIENCE, 2009, 323 (5922) :1718-1722

[2] Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters [J].

Berge, KE ;

Tian, H ;

Graf, GA ;

Yu, LQ ;

Grishin, NV ;

Schultz, J ;

Kwiterovich, P ;

Shan, B ;

Barnes, R ;

Hobbs, HH .

SCIENCE, 2000, 290 (5497) :1771-1775

[3] Retinoid Binding Properties of Nucleotide Binding Domain 1 of the Stargardt Disease-associated ATP Binding Cassette (ABC) Transporter, ABCA4 [J].

Biswas-Fiss, Esther E. ;

Affet, Stephanie ;

Ha, Malissa ;

Biswas, Subhasis B. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (53) :44097-44107

[4] LENTIVIRAL HEMATOPOIETIC CELL GENE THERAPY FOR X-LINKED ADRENOLEUKODYSTROPHY [J].

Cartier, Nathalie ;

Hacein-Bey-Abina, Salima ;

Bartholomae, Cynthia C. ;

Bougneres, Pierre ;

Schmidt, Manfred ;

Von Kalle, Christof ;

Fischer, Alain ;

Cavazzana-Calvo, Marina ;

Aubourg, Patrick .

METHODS IN ENZYMOLOGY, VOL 507: GENE TRANSFER VECTORS FOR CLINICAL APPLICATION, 2012, 507 :187-198

[5] Reconstitution of Glucosylceramide Flip-Flop across Endoplasmic Reticulum IMPLICATIONS FOR MECHANISM OF GLYCOSPHINGOLIPID BIOSYNTHESIS [J].

Chalat, Madhavan ;

Menon, Indu ;

Turan, Zeynep ;

Menon, Anant K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (19) :15523-15532

[6] Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance [J].

Chen, Kevin G. ;

Sikic, Branimir I. .

CLINICAL CANCER RESEARCH, 2012, 18 (07) :1863-1869

[7] Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism [J].

Coelho, David ;

Kim, Jaeseung C. ;

Miousse, Isabelle R. ;

Fung, Stephen ;

du Moulin, Marcel ;

Buers, Insa ;

Suormala, Terttu ;

Burda, Patricie ;

Frapolli, Michele ;

Stucki, Martin ;

Nuernberg, Peter ;

Thiele, Holger ;

Robenek, Horst ;

Hoehne, Wolfgang ;

Longo, Nicola ;

Pasquali, Marzia ;

Mengel, Eugen ;

Watkins, David ;

Shoubridge, Eric A. ;

Majewski, Jacek ;

Rosenblatt, David S. ;

Fowler, Brian ;

Rutsch, Frank ;

Baumgartner, Matthias R. .

NATURE GENETICS, 2012, 44 (10) :1152-+

[8] Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes [J].

Contreras, F. -Xabier ;

Sanchez-Magraner, Lissete ;

Alonso, Alicia ;

Goni, Felix M. .

FEBS LETTERS, 2010, 584 (09) :1779-1786

[9] Pathways by Which Reconstituted High-Density Lipoprotein Mobilizes Free Cholesterol From Whole Body and From Macrophages [J].

Cuchel, Marina ;

Lund-Katz, Sissel ;

de la Llera-Moya, Margarita ;

Millar, John S. ;

Chang, David ;

Fuki, Ilia ;

Rothblat, George H. ;

Phillips, Michael C. ;

Rader, Daniel J. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (03) :526-U341

[10] The ATP-Binding Cassette Transporter-2 (ABCA2) Increases Endogenous Amyloid Precursor Protein Expression and Abeta Fragment Generation [J].

Davis, W., Jr. .

CURRENT ALZHEIMER RESEARCH, 2010, 7 (07) :566-577

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