Transport to the photoreceptor outer segment by myosin VIIa and kinesin II

被引：56

作者：

Williams, DS ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

VISION RESEARCH | 2002年 / 42卷 / 04期

关键词：

photoreceptor; opsin; myosin VIIa; kinesin II; shaker1; mice; Cre-loxP knockout mice;

D O I：

10.1016/S0042-6989(01)00228-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This paper reviews our studies in which we have used mutant mice to investigate the roles of myosin Vila and kinesin 11 in the transport of proteins to the photoreceptor outer segment. These studies suggest that both motors participate in moving opsin along the connecting cilium. Given the velocities measured for these motors in vitro. it is predicted that the resulting concentration of opsin in the plasma membrane of the connecting cilium is surprisingly low. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：455 / 462

页数：8

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