In vitro selection of aptamers: The dearth of pure reason

被引：57

作者：

Uphoff, KW ^{[1
]}

Bell, SD ^{[1
]}

Ellington, AD ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT BIOL,BLOOMINGTON,IN 47405

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 03期

基金：

美国国家科学基金会;

关键词：

INVITRO;

D O I：

10.1016/S0959-440X(96)80045-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vitro selection experiments are now routinely used to identify functional nucleic acid residues and structures, and have become a tool for studying molecular recognition, molecular biology, and molecular evolution. Technical innovations that have been made during the past year include the use of modified monomers to increase stability and photocross-linking reagents to improve affinity. These advances should dramatically increase the utility of aptamers in the future.

引用

收藏

页码：281 / 288

页数：8

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