Autoimmune diagnostics in diabetes mellitus

被引：37

作者：

Seissler, J ^{[1
]}

Scherbaum, WA ^{[1
]}

机构：

[1] Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Clin, D-40225 Dusseldorf, Germany

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2006年 / 44卷 / 02期

关键词：

autoantibodies; diabetes mellitus; glutamic acid decarboxylase; insulin autoantibodies; latent autoimmune diabetes in adults (LADA); type; 1; diabetes; tyrosine phosphatase IA-2;

D O I：

10.1515/CCLM.2006.025

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

Type 1 diabetes results from a specific destruction of the insulin-producing beta-cells of the pancreas. The disease is characterized by the appearance of specific autoantibodies against islet cell antigens. Autoantibodies to insulin, glutamic acid decarboxylase, tyrosine phosphatase 1A-2 and cytoplasmic islet cell antibodies are useful markers for the differential diagnosis of type 1 diabetes when clinical and metabolic criteria alone do not allow definite classification. Autoimmune diagnostics is of particular importance in adults to discriminate between type 1 and type 2 diabetes and to assess the diagnosis of latent autoimmune diabetes in adults.

引用

页码：133 / 137

页数：5

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