Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

被引：45

作者：

de Jong, BA

Westendorp, RGJ

Eskdale, J

Uitdehaag, BMJ

Huizinga, TWJ

机构：

[1] Leiden Univ, Ctr Med, Dept Rheumatol, NL-2300 RC Leiden, Netherlands

[2] Univ Glasgow, Dept Clin Epidemiol, Glasgow, Lanark, Scotland

[3] Univ Glasgow, Dept Internal Med, Glasgow, Lanark, Scotland

[4] Univ Glasgow, Dept Surg, Glasgow, Lanark, Scotland

[5] VU Med Ctr, Dept Neurol, Amsterdam, Netherlands

来源：

HUMAN IMMUNOLOGY | 2002年 / 63卷 / 04期

关键词：

multiple sclerosis; interleukin-10; immunogenetics; single nucleotide polymorphisms; etiology;

D O I：

10.1016/S0198-8859(02)00369-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.

引用

页码：281 / 285

页数：5

共 24 条

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