Translocation of HSP27 and MKBP in ischemic heart

被引：37

作者：

Yoshida, K ^{[1
]}

Aki, T

Harada, K

Shama, KMA

Kamoda, Y

Suzuki, A

Ohno, S

机构：

[1] Yamaguchi Univ, Sch Med, Dept Legal Med, Yamaguchi 7558505, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Legal Med, Tokyo 1130033, Japan

[3] Yokohama City Univ, Sch Med, Dept Mol Biol, Kanagawa 2360004, Japan

来源：

CELL STRUCTURE AND FUNCTION | 1999年 / 24卷 / 04期

关键词：

HSP27; MKBP; translocation; ischemia; myofibril; oxidative stress;

D O I：

10.1247/csf.24.181

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HSP27 and MKBP translocate from the cytosolic to myofibril fraction in ischemic rat heart as demonstrated by immunoblotting. Immunohistochemistry analysis showed that ischemia enhances the Z line labeling of HSP27 and MKBP. Two dimensional gel electrophoresis showed that ischemia increases the hyperphosphorylated form of HSP27. These data suggest that HSP27 and MKBP may be involved in the Z line protection against postischemic reperfusion injury.

引用

页码：181 / 185

页数：5

共 23 条

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