Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43

被引:69
作者
Bonavia, A
Arbour, N
Yong, VW
Talbot, PJ
机构
[1] UNIV QUEBEC,INST ARMAND FRAPPIER,LAB NEUROIMMUNOVIROL,VIROL RES CTR,LAVAL,PQ H7N 4Z3,CANADA
[2] MCGILL UNIV,MONTREAL NEUROL INST,NEUROIMMUNOL UNIT,MONTREAL,PQ H3A 2B4,CANADA
关键词
D O I
10.1128/JVI.71.1.800-806.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We evaluated the ability of human coronaviruses to infect primary cultures of human neural cells. Double immunofluorescence with antibodies to virus and cell markers showed infection of fetal astrocytes and of adult microglia and astrocytes by strain OC43. RNA amplification revealed infection of fetal astrocytes, adult microglia, and a mixed culture of adult oligodendrocytes and astrocytes by strain 229E. Infectious virus was released only from fetal astrocytes, with higher titers for OC43. Human coronaviruses have the capacity to infect some cells of the central nervous system, although infection of adult cells appears abortive.
引用
收藏
页码:800 / 806
页数:7
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