Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

被引：27

作者：

Aderibigbe, Blessing ^{[1
]}

Aderibigbe, Isiaka ^{[2
]}

Popoola, Patricia ^{[2
]}

机构：

[1] Univ Ft Hare, Dept Chem, Alice Campus, ZA-5700 Eastern Cape, South Africa

[2] Tshwane Univ Technol, Dept Chem & Met Engn, ZA-0001 Pretoria, South Africa

来源：

PHARMACEUTICS | 2017年 / 9卷 / 01期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

bisphosphonates; drug delivery systems; biomaterials; nanocapsules; NITROGEN-CONTAINING BISPHOSPHONATE; METASTATIC BONE-DISEASE; IN-VITRO EVALUATION; TARGETED DRUG-DELIVERY; BREAST-CANCER; ZOLEDRONIC ACID; PHYSICOCHEMICAL CHARACTERIZATION; OSTEOCLAST FORMATION; POLYETHYLENE-GLYCOL; ALENDRONATE SODIUM;

D O I：

10.3390/pharmaceutics9010002

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and low intestinal adsorption. These shortcomings have resulted in several researchers developing delivery systems that can enhance their overall therapeutic effectiveness. This review provides a detailed overview of the published studies on delivery systems designed for the delivery of bisphosphonates and the corresponding in vitro/in vivo results.

引用

页数：24

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