Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats

被引：102

作者：

Rana, SVS

Verma, S

机构：

[1] Department of Zoology, Ch. Charan Singh University, Meerut

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1996年 / 51卷 / 02期

关键词：

cadmium; glutathione; alpha-tocopherol; selenium; malondialdehyde;

D O I：

10.1007/BF02785435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased intake of Cd results in its retention and in peroxidative damage in soft tissues. Coadministration of antioxidants, viz., glutathione (GSH), alpha-tocopherol, and Se, restricted the uptake and distribution of Cd in liver and kidney of rats. Moreover, no rise in malondialdehyde was recorded. Although possible antioxidative mechanisms manifested by GSH, alpha-tocopherol, and Se have been discussed, it is hypothesized that GSH functions as a Cd chelator. Glutathione yielded favorable effects in comparison to Se and alpha-tocopherol.

引用

页码：161 / 168

页数：8

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