Pluripotency re-centered around Esrrb

被引：19

作者：

Papp, Bernadett ^{[1
]}

Plath, Kathrin ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Jonsson Comprehens Canc Ctr,Dept Biol Chem, David Geffen Sch Med,Mol Biol Inst, Los Angeles, CA 90024 USA

来源：

EMBO JOURNAL | 2012年 / 31卷 / 22期

关键词：

EMBRYONIC STEM-CELLS; SELF-RENEWAL; NANOG; TRANSCRIPTION; NETWORK; TARGET; OCT4;

D O I：

10.1038/emboj.2012.285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The orphan nuclear receptor estrogen-related receptor b (Esrrb) is a vital component of the core pluripotency network in embryonic stem cells (ESCs). However, its function is not clear and the identity of potential upstream regulators has remained elusive. Three elegant reports (Festuccia et al, 2012; Martello et al, 2012; Percharde et al, 2012) have now elucidated the role of Esrrb in ESC self-renewal and reprogramming.

引用

页码：4255 / 4257

页数：3

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