Mechanisms of Acupuncture Effect on Alzheimer's Disease in Animal-Based Researches

被引：46

作者：

Cao, Yan ^{[1
,2
]}

Zhang, Li-Wen ^{[1
,2
]}

Wang, Jian ^{[2
]}

Du, Si-Qi ^{[1
]}

Xiao, Ling-Yong ^{[1
]}

Tu, Jian-Feng ^{[1
]}

Liu, Cun-Zhi ^{[1
]}

机构：

[1] Capital Med Univ, Acupuncture & Moxibust Dept, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Jinan, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 05期

基金：

北京市自然科学基金;

关键词：

Acupuncture; Alzheimer's disease; Cognitive function; Complementary and Alternative medicine; Mechanisms; TRIOSE PHOSPHATE ISOMERASE; MILD COGNITIVE IMPAIRMENT; LONG-TERM POTENTIATION; OXIDATIVE STRESS; HIPPOCAMPUS; APOPTOSIS; CELLS; TAU; STIMULATION; HYPOTHESIS;

D O I：

10.2174/1568026615666150813144942

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Alzheimer's disease is the most common type of dementia in the aging population worldwide. The etiology and treatment of Alzheimer's disease are still not very clear. Finding a new treatment is urgent due to the increasing population aging. Acupuncture has been practicing in China for more than 3000 years and reported to be beneficial in treating cognitive impairment of Alzheimer's disease. This paper reviews the recent development on the effect of acupuncture on Alzheimer's disease in animal-based researches. It is suggested that acupuncture improves cognitive function of Alzheimer's disease by regulating glucose metabolism, enhancing neurotransmission as well as reducing oxidative stress, A beta protein deposition, and neuronal apoptosis. However, it is still difficult to clarify which specific signaling pathway contributes to the acupuncture effect. Better designed studies are recommended to investigate the effects of acupuncture on Alzheimer's disease.

引用

页码：574 / 578

页数：5

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