Emerging evidence on the pathobiology of mucositis

被引：105

作者：

Al-Dasooqi, Noor ^{[1
]}

Sonis, Stephen T. ^{[2
]}

Bowen, Joanne M. ^{[3
]}

Bateman, Emma ^{[1
]}

Blijlevens, Nicole ^{[4
]}

Gibson, Rachel J. ^{[5
]}

Logan, Richard M. ^{[6
]}

Nair, Raj G. ^{[7
,8
]}

Stringer, Andrea M. ^{[9
]}

Yazbeck, Roger ^{[9
]}

Elad, Sharon ^{[10
]}

Lalla, Rajesh V. ^{[11
,12
]}

机构：

[1] Univ Adelaide, Discipline Med, Adelaide, SA 5000, Australia

[2] Brigham & Womens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Univ Adelaide, Discipline Physiol, Adelaide, SA 5000, Australia

[4] Univ Med Ctr Nijmegen, Dept Haematol, NL-6500 HB Nijmegen, Netherlands

[5] Univ Adelaide, Discipline Anat & Pathol, Adelaide, SA 5000, Australia

[6] Univ Adelaide, Sch Dent, Adelaide, SA 5005, Australia

[7] Griffith Univ, Discipline Oral Med, Gold Coast, Qld, Australia

[8] Queensland Hlth, Dept Haematol & Oncol, Gold Coast, Qld, Australia

[9] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia

[10] Univ Rochester, Med Ctr, Div Oral Med, Eastman Inst Oral Hlth, Rochester, NY 14642 USA

[11] Univ Connecticut, Ctr Hlth, Sect Oral Med, Farmington, CT 06030 USA

[12] Univ Connecticut, Ctr Hlth, Neag Comprehens Canc Ctr, Farmington, CT 06030 USA

来源：

SUPPORTIVE CARE IN CANCER | 2013年 / 21卷 / 11期

关键词：

Mucosal injury; Cancer therapy; Targeted drugs; Toxicity; Alimentary tract; Pharmacogenetics; NF-KAPPA-B; ALIMENTARY-TRACT MUCOSITIS; CYCLOOXYGENASE-2; COX-2; EXPRESSION; TIGHT JUNCTION PERMEABILITY; METASTATIC BREAST-CANCER; PRO-INFLAMMATORY CYTOKINES; STEM-CELL TRANSPLANTATION; INDUCED ORAL MUCOSITIS; DARK AGOUTI RAT; MUCOSAL INJURY;

D O I：

10.1007/s00520-013-1900-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.

引用

页码：3233 / 3241

页数：9

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