Adipogenesis:: cellular and molecular aspects

被引：222

作者：

Fève, B ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Med Bicetre, INSERM, U693, F-94270 Le Kremlin Bicetre, France

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2005年 / 19卷 / 04期

关键词：

adipogenesis; obesity; lipodystrophy; adipocyte; transcription factor;

D O I：

10.1016/j.beem.2005.07.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent diabetes and cardiovascular disease. In the past three decades, significant advances have been made in delineating the key transcription factors of adipogenesis, as well as extracellular effectors and intracellular signalling pathways that regulate fat cell formation. This review focuses on in vitro models of adipocyte differentiation, and on the balance between pro- and anti-adipogenic factors that drive the adipocyte differentiation process. Full understanding of the mechanisms of adipose tissue differentiation represents a major issue to develop a comprehensive strategy to prevent and treat obesity.

引用

页码：483 / 499

页数：17

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