MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma

被引：49

作者：

Boonla, Chanchai ^{[1
]}

Sripa, Banchob ^{[2
]}

Thuwajit, Peti ^{[1
]}

Cha-On, Ubon ^{[1
]}

Puapairoj, Anucha ^{[2
]}

Miwa, Masanao ^{[3
]}

Wongkham, Sopit ^{[1
]}

机构：

[1] Khon Kaen Univ, Fac Med, Dept Biochem, Liver Fluke & Cholangiocarcinoma Res Ctr, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Med, Dept Pathol, Liver Fluke & Cholangiocarcinoma Res Ctr, Khon Kaen 40002, Thailand

[3] Univ Tskuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 32期

关键词：

Cholangiocarcinoma; Mucin; MUC1; MUC5AC; Invasion; Survival; Immunohistochemistry;

D O I：

10.3748/wjg.v11.i32.4939

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined. METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87 cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated. RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1 or MUC5AC, and 9% expressed neither. High MUC1 immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001), whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026), histological grading and stage of tumor represented the least probability of survival. CONCLUSION: MUC1 is overexpressed in liver fluke-associated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：4939 / 4946

页数：8

共 61 条

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