Ascorbic acid and α-tocopherol attenuate methylmalonic acid-induced convulsions

被引：62

作者：

Fighera, MR

Queiroz, CM

Stracke, MP

Brauer, MCN

González-Rodríguez, LL

Frussa, R

Wajner, M

de Mello, CF ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Satan Maria, Brazil

[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 Sao Paulo, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Basicas Saude, Dept Bioquim, BR-90050170 Porto Alegre, RS, Brazil

来源：

NEUROREPORT | 1999年 / 10卷 / 10期

关键词：

antioxidants; ascorbic acid; convulsion; excitotoxicity; glutamate; melatonin; methylmalonic acid; succinate dehydrogenase; alpha-tocopherol;

D O I：

10.1097/00001756-199907130-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically injected with alpha-tocopherol (40 mg kg(-1), i.p.), melatonin (5 mg kg(-1), i.p.) or vehicle for 7 days. Buffered MMA (6 mu mol/2 mu l) or NaCl (9 mu mol/2 mu l) was injected intrastriatally and the animals were observed for the appearance of clonic or tonic-clonic convulsions and rotational behavior. Ascorbic acid (100 mg kg(-1), s.c.) was administered 30 min before MMA injection. alpha-Tocopherol and ascorbic acid pretreatment decreased the duration of the convulsive episodes and the rotational behavior elicited by MMA, This study provides evidence that free radical generation may participate in the convulsant effects of methylmalonic acid. NeuroReport 10:2039-2043 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2039 / 2043

页数：5

共 29 条

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