The design and synthesis of inhibitors of adenosine 5′-monophosphate deaminase

被引：35

作者：

Lindell, SD ^{[1
]}

Moloney, BA ^{[1
]}

Hewitt, BD ^{[1
]}

Earnshaw, CG ^{[1
]}

Dudfield, PJ ^{[1
]}

Dancer, JE ^{[1
]}

机构：

[1] AgrEvo UK Ltd, Saffron Walden CB10 1XL, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

enzyme inhibitors; herbicides; nucleosides; nucleotides;

D O I：

10.1016/S0960-894X(99)00298-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1985 / 1990

页数：6

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