Unraveling the therapeutic potential of the Hedgehog pathway in cancer

被引：445

作者：

Amakye, Dereck ^{[1
]}

Jagani, Zainab ^{[2
]}

Dorsch, Marion ^{[3
]}

机构：

[1] Novartis Pharmaceut, E Hanover, NJ USA

[2] Novartis Inst Biomed Res, Cambridge, MA USA

[3] Agios Pharmaceut, Cambridge, MA USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 11期

关键词：

SMALL-MOLECULE INHIBITORS; BASAL-CELL CARCINOMAS; PHASE-II TRIAL; SONIC-HEDGEHOG; MOUSE MODEL; STEM-CELLS; HUMAN HOMOLOG; MEDULLOBLASTOMA FORMATION; SMOOTHENED MUTATION; SIGNALING PATHWAY;

D O I：

10.1038/nm.3389

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major progress has been made in recent years in the development of Hedgehog (Hh) pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results have been obtained in cancers that harbor activating mutations of the Hh pathway, such as basal cell carcinoma and medulloblastoma. However, for many cancers, in which Hh ligand overexpression is thought to drive tumor growth, results have been disappointing. Here we review the preclinical data that continue to shape our understanding of the Hh pathway in tumorigenesis and the emerging clinical experience with smoothened inhibitors.

引用

页码：1410 / 1422

页数：13

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