Regulation of the PTEN phosphatase

被引：151

作者：

Gericke, Arne

Munson, Mary

Ross, Alonzo H.

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

[2] Kent State Univ, Dept Chem, Kent, OH 44242 USA

来源：

GENE | 2006年 / 374卷

关键词：

tumor suppressor; phosphatidylinositol; interfacial enzyme; phosphorylation; protein tethering; nuclear transport;

D O I：

10.1016/j.gene.2006.02.024

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatidylinositol phosphate phosphatase and is frequently inactivated in human cancers. The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P-3 levels. P13K is regulated by a variety of intracellular and extracellular signals, but little is known about the regulation of PTEN. In this article, we review control of PTEN function by phosphorylation as well as by binding of lipid and protein partners. (c) 2006 Elsevier B.V. All rights reserved.

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页码：1 / 9

页数：9

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