Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV

被引：77

作者：

Nicolaou, KC

Trujillo, JI

Chibale, K

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(97)00567-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design, synthesis and preliminary biological evaluation of carbohydrate-based non-peptide mimetics of the potent peptidic antagonist of alpha(v) beta(3), and alpha(v) beta(5), pentapeptide cRGDFV (1) is presented. The design was based on the NMR-determined structure of 1. (C) 1997 Elsevier Science Ltd.

引用

页码：8751 / 8778

页数：28

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