Conducting polymer-hydrogel blends for electrochemically controlled drug release devices

被引：33

作者：

Barthus, Rosangela C. ^{[1
]}

Lira, Luiz M. ^{[1
]}

de Torresi, Susana I. Cordoba ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, BR-05513970 Sao Paulo, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2008年 / 19卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

factorial design; polypyrrole-polyacrilamide blends; drug delivery; electrochemically controlled release;

D O I：

10.1590/S0103-50532008000400004

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy.

引用

页码：630 / 636

页数：7

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