Evidence of Intrathecal Immunoglobulin Synthesis in Stroke A Cohort Study

被引：39

作者：

Pruess, Harald ^{[1
,2
,3
,4
]}

Iggena, Deetje ^{[1
,2
,3
]}

Baldinger, Tina ^{[1
,2
,3
]}

Prinz, Vincent ^{[1
,2
,3
]}

Meisel, Andreas ^{[1
,2
,3
]}

Endres, Matthias ^{[1
,2
,3
]}

Dirnagl, Ulrich ^{[1
,2
,3
]}

Schwab, Jan M. ^{[1
,2
,3
]}

机构：

[1] Charite, Dept Neurol, D-10117 Berlin, Germany

[2] Charite, Dept Expt Neurol, Ctr Stroke Res, D-10117 Berlin, Germany

[3] Charite, Ctr Excellence NeuroCure, D-10117 Berlin, Germany

[4] Harvard Univ, Sch Med, Div Immunol, Dept Microbiol & Immunobiol, Boston, MA USA

来源：

ARCHIVES OF NEUROLOGY | 2012年 / 69卷 / 06期

关键词：

CEREBROSPINAL-FLUID; OLIGOCLONAL IMMUNOGLOBULINS; ANTIBODIES; BRAIN;

D O I：

10.1001/archneurol.2011.3252

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Immune mechanisms are included in stroke pathophysiologic factors, but the frequency and role of intrathecal antibodies is unclear and diagnostic tests are not routinely performed on cerebrospinal fluid (CSF). Objective: To determine the frequency of intrathecal immunoglobulin synthesis in a well-characterized cohort of patients who experienced "noninflammatory" acute stroke. Design: Retrospective cohort study. Setting: University hospital neurology department. Patients: Patients (n=318) with stroke who were undergoing lumbar puncture during diagnostic workup and 79 control patients. Results: Cerebrospinal fluid-specific immunoglobulin (IgG, IgM, and IgA) synthesis was significantly (P < .001) more frequent after stroke (24.8%) compared with the incidence in age-and sex-matched controls (2.5%). Furthermore, 31.3% of stroke patients demonstrated blood-brain barrier dysfunction and 18.1% displayed pleocytosis. Conclusion: The strong association between CSFspecific immunoglobulin synthesis and stroke suggests a role in the development of cerebral ischemia and might constitute an immunologically defined stroke subgroup. Arch Neurol. 2012; 69(6): 714-717. Published online February 27, 2012. doi:10.1001/archneurol.2011.3252

引用

页码：714 / 717

页数：4

共 14 条

[1] Antibodies to brain antigens following stroke [J].