An enantioselective route to trans-2,6-disubstituted piperidines

被引：25

作者：

Chackalamannil, S

Wang, YG

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

TETRAHEDRON | 1997年 / 53卷 / 32期

关键词：

D O I：

10.1016/S0040-4020(97)00377-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (S)-2-methyl tetrahydropyridine-N-oxide (4), a key intermediate for the enantioselective construction of trans-2,6-disubstituted piperidines via [3+2] nitrone cycloaddition reaction, is described. Nitrone 4 was elaborated to the fire ant venom alkaloid (+)-solenopsin-A (2) via intermediate 14. (C) 1997 Elsevier Science Ltd.

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页码：11203 / 11210

页数：8

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