A low dose of streptozotocin prevents kainic acid-induced seizures and lethal effects in the rat

被引：3

作者：

Kim, HC ^{[1
]}

Im, DH ^{[1
]}

Jhoo, WK ^{[1
]}

Kim, C ^{[1
]}

Wie, MB ^{[1
]}

机构：

[1] SAMCHUNDANG PHARMACEUT CO,CTR RES & DEV,CHUNCHON,SOUTH KOREA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1997年 / 24卷 / 07期

关键词：

kainic acid; neuroprotective effect; nitric oxide; streptozotocin;

D O I：

10.1111/j.1440-1681.1997.tb01235.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of streptozotocin (STZ), a nitric oxide (NO) donor, on kainic acid (KA)-induced neurotoxicity was examined in Sprague-Dawley rats. 2. The administration of KA (8 mg/kg, i.p.) produced significant neurotoxicity accompanied with increased immunoreactivity for Fos-related antigen in the rat hippocampus. 3. Pretreatment with STZ (15 mg/kg, i.m.) significantly blocked the neurotoxicity induced by KA. 4. Thus, the neuroprotective effect of STZ may, at least in part, reflect the role of NO in inhibiting seizures.

引用

页码：503 / 505

页数：3

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