APOPTOSIS Refined and lethal

被引:77
作者
Burgess, Darren J.
机构
关键词
D O I
10.1038/nrc3462
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Two studies now describe new approaches to targeting anti-apoptotic BCL-2 family members in various cancer types.
引用
收藏
页码:79 / 79
页数:1
相关论文
共 2 条
[1]
Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models [J].
Corcoran, Ryan B. ;
Cheng, Katherine A. ;
Hata, Aaron N. ;
Faber, Anthony C. ;
Ebi, Hiromichi ;
Coffee, Erin M. ;
Greninger, Patricia ;
Brown, Ronald D. ;
Godfrey, Jason T. ;
Cohoon, Travis J. ;
Song, Youngchul ;
Lifshits, Eugene ;
Hung, Kenneth E. ;
Shioda, Toshi ;
Dias-Santagata, Dora ;
Singh, Anurag ;
Settleman, Jeffrey ;
Benes, Cyril H. ;
Mino-Kenudson, Mari ;
Wong, Kwok-Kin ;
Engelman, Jeffrey A. .
CANCER CELL, 2013, 23 (01) :121-128
[2]
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets [J].
Souers, Andrew J. ;
Leverson, Joel D. ;
Boghaert, Erwin R. ;
Ackler, Scott L. ;
Catron, Nathaniel D. ;
Chen, Jun ;
Dayton, Brian D. ;
Ding, Hong ;
Enschede, Sari H. ;
Fairbrother, Wayne J. ;
Huang, David C. S. ;
Hymowitz, Sarah G. ;
Jin, Sha ;
Khaw, Seong Lin ;
Kovar, Peter J. ;
Lam, Lloyd T. ;
Lee, Jackie ;
Maecker, Heather L. ;
Marsh, Kennan C. ;
Mason, Kylie D. ;
Mitten, Michael J. ;
Nimmer, Paul M. ;
Oleksijew, Anatol ;
Park, Chang H. ;
Park, Cheol-Min ;
Phillips, Darren C. ;
Roberts, Andrew W. ;
Sampath, Deepak ;
Seymour, John F. ;
Smith, Morey L. ;
Sullivan, Gerard M. ;
Tahir, Stephen K. ;
Tse, Chris ;
Wendt, Michael D. ;
Xiao, Yu ;
Xue, John C. ;
Zhang, Haichao ;
Humerickhouse, Rod A. ;
Rosenberg, Saul H. ;
Elmore, Steven W. .
NATURE MEDICINE, 2013, 19 (02) :202-208