Solid phase synthesis of beta-peptides via Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones

被引：32

作者：

Marti, RE ^{[1
]}

Bleicher, KH ^{[1
]}

Bair, KW ^{[1
]}

机构：

[1] NOVARTIS PHARMACEUT CORP,DEPT METAB & CARDIOVASC DIS,E HANOVER,NJ 07936

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(97)01420-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis of beta-peptides and beta-amino acid containing peptides via Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones is described. Syntheses were carried out on Wang, Rink and 2-chlorotrityl resins. Quantitative coupling efficiency gave highly pure compounds as proven by RP-HPLC and MS. (C) 1997 Elsevier Science Ltd.

引用

页码：6145 / 6148

页数：4

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