Eloquent silence: developmental functions of Class I histone deacetylases

被引：75

作者：

Cunliffe, Vincent T. ^{[1
,2
]}

机构：

[1] Univ Sheffield, MRC Ctr Dev & Biomed Genet, Sheffield S10 2TN, S Yorkshire, England

[2] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 05期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.gde.2008.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histone deacetylases (HDACs) are essential catalytic components of the transcription silencing machinery and they play important roles in the programming of multicellular development. HDACs are present within multisubunit protein complexes, other components of which govern HDAC target gene specificity by controlling interactions with sequence-specific DNA-binding proteins. Here, I review the different developmental roles of the Sin3, NuRD, CoREST and NCoR/SMRT Class I HDAC complexes. With their distinct subunit composition, these versatile molecular devices function in many different settings, to promote axis specification and tissue patterning, to maintain stem cell pluripotency, facilitate self-renewal, guide lineage commitment and drive cell differentiation.

引用

页码：404 / 410

页数：7

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[1] MAB21L2, a vertebrate member of the male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1 [J].