Diclofenac suppository analgesia for transrectal ultrasound guided biopsies of the prostate: A double-blind, randomized controlled trial

被引:34
作者
Haq, A
Patel, HRH
Habib, MR
Donaldson, PJ
Parry, JRW
机构
[1] UCL, Inst Urol & Nephrol, London W1W 7EY, England
[2] Ipswich Hosp, Dept Urol, Ipswich, England
关键词
prostate; biopsy; pain; diclofenac; suppositories;
D O I
10.1097/01.ju.0000115706.19605.e4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: A significant proportion of men undergoing transrectal ultrasound (TRUS) and prostate biopsy report pain during the procedure. A number of different methods of pain relief have been suggested in the literature. We prospectively evaluated the effect of diclofenac suppositories on pain experienced by men undergoing TRUS and prostate biopsy. Materials and Methods: A prospective, randomized, double-blind, placebo controlled study was performed in 72 patients requiring prostate biopsy. Patients were randomly assigned to receive 100 mg diclofenac or placebo 1 hour prior to the procedure. They were asked to indicate on a 10 cm visual analogue scale the degree of discomfort during the procedure. The patients were then seen 2 weeks later and any morbidity, including infection and bleeding, was assessed. Results: Patients given diclofenac had significantly lower pain scores than those given placebo (2.8 vs 4.9, p <0.001). The 2 groups were similar in regard to age, prostate volume, biopsy number, prostate specific antigen, histological diagnosis and complication rate. Conclusions: Rectal administration of diclofenac 1 hour prior to TRUS and prostate biopsy is a simple procedure that significantly relieves the pain experienced with no increase in morbidity. With the trend toward more core samples, screening for prostate cancer and the younger age of patients undergoing biopsy we urge urologists to provide analgesia for this painful procedure.
引用
收藏
页码:1489 / 1491
页数:3
相关论文
共 14 条
[1]   Towards complete and,accurate reporting of studies of diagnostic accuracy: the STARD initiative [J].
Bossuyt, PM ;
Reitsma, JB ;
Bruns, DE ;
Gatsonis, CA ;
Glasziou, PP ;
Irwig, LM ;
Lijmer, JG ;
Moher, D ;
Rennie, D ;
de Vet, HCE .
BRITISH MEDICAL JOURNAL, 2003, 326 (7379) :41-44
[2]  
Crundwell MC, 1999, BJU INT, V83, P792
[3]  
Desgrandchamps F, 1999, BJU INT, V83, P1007
[4]  
HAQ A, 2000, BJU INT, V1, P134
[5]   Patient tolerance of transrectal ultrasound-guided biopsy of the prostate [J].
Irani, J ;
Fournier, F ;
Bon, D ;
Gremmo, E ;
Dore, B ;
Aubert, J .
BRITISH JOURNAL OF UROLOGY, 1997, 79 (04) :608-610
[6]   Editorial: Transrectal ultrasound guided prostate biopsy - Defining a new standard [J].
Klein, EA ;
Zippe, CD .
JOURNAL OF UROLOGY, 2000, 163 (01) :179-180
[7]  
MUSOOD J, 2002, J UROL S, V167, P332
[8]   Increased patient satisfaction from transrectal ultrasonography and biopsy under sedation [J].
Peters, JL ;
Thompson, AC ;
McNicholas, TA ;
Hines, JEW ;
Hanbury, DC ;
Boustead, GB .
BJU INTERNATIONAL, 2001, 87 (09) :827-830
[9]   Risks and complications of transrectal ultrasound guided prostate needle biopsy:: A prospective study and review of the literature [J].
Rodríguez, LV ;
Terris, MK .
JOURNAL OF UROLOGY, 1998, 160 (06) :2115-2120
[10]   Pain after transrectal ultrasonography-guided prostate biopsy: the advantages of periprostatic local anaesthesia [J].
Seymour, H ;
Perry, MJA ;
Lee-Elliot, C ;
Dundas, D ;
Patel, U .
BJU INTERNATIONAL, 2001, 88 (06) :540-544