Modular evolution of the integrase domain in the Ty3/Gypsy class of LTR retrotransposons

被引：167

作者：

Malik, HS ^{[1
]}

Eickbush, TH ^{[1
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 06期

关键词：

D O I：

10.1128/JVI.73.6.5186-5190.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A phylogenetic analysis of the Ty3/Gqpsy group of retrotransposons identified a conserved domain (GPY/F) present in the integrases of several members of this group as well as of certain vertebrate retroviruses, The analysis suggested an evolutionary scheme for the acquisition and loss of the GPY/F domain as well as the acquisition of a chromodomain module in the integrase encoded by this group of elements that may direct targeting specificity in the host genome.

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页码：5186 / 5190

页数：5

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