Isolation and structure determination of TMC-151s:: Novel polyketide antibiotics from Gliocladium catenulatum Gilman & Abbott TC 1280

被引：47

作者：

Kohno, J ^{[1
]}

Nishio, M ^{[1
]}

Sakurai, M ^{[1
]}

Kawano, K ^{[1
]}

Hiramatsu, H ^{[1
]}

Kameda, N ^{[1
]}

Kishi, N ^{[1
]}

Yamashita, T ^{[1
]}

Okuda, T ^{[1
]}

Komatsubara, S ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 25期

关键词：

D O I：

10.1016/S0040-4020(99)00408-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six new antibiotics, TMC-151 A-F (2-7) have been isolated from organic extracts of the fermentation broth of Gliocladium catenulatum Gilman & Abbott TC 1280, isolated from a soil sample. Their structures including the absolute stereochemistries, were determined by extensive analyses of NMR and X-ray crystallography, and degradation studies. TMC-151s are novel polyketides containing D-mannopyranoside and D-mannitol or D-arabitol. These antibiotics showed moderate cytotoxicity to several tumor cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7771 / 7786

页数：16

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