Central chemosensitivity of respiration: a brief overview

被引:62
作者
Ballantyne, D [1 ]
Scheid, P [1 ]
机构
[1] Ruhr Univ Bochum, Inst Physiol, D-44780 Bochum, Germany
来源
RESPIRATION PHYSIOLOGY | 2001年 / 129卷 / 1-2期
关键词
carbon dioxide; central chemosensitivity; control of breathing;
D O I
10.1016/S0034-5687(01)00297-3
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In this introductory article we make use of the work reviewed in detail by a number of contributors to this Special Issue (Respir. Physiol., 2001) to provide an outline of current approaches to identifying brainstem CO2/pH-chemosensitive neurones. The section headings which we have adopted are intended to reflect particular issues rather than experimental techniques, though some of these issues arise out of the choice of preparation and the advantages and limitations which follow from such a choice. We have also considered whether, in spite of the diversity in the kinds of neurones usually considered to be chemosensitive, there are any indications for shared or uniform features. Again, this is based on the material published together in this volume. Finally, and more speculatively, we suggest that the dendritic organization of chemosensitive neurones may play an important role in chemoreception. not simply as a means of sampling the stimulus but also as a way of compartmentalizing the effects of pH in relation to other aspects of a neurone's activity. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:5 / 12
页数:8
相关论文
共 24 条
[1]   Synchronized rhythms in chemosensitive neurons of the locus coeruleus in the absence of chemical synaptic transmission [J].
Andrzejewski, M ;
Mückenhoff, K ;
Scheid, P ;
Ballantyne, D .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :123-140
[2]   Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia [J].
Baker, TL ;
Fuller, DD ;
Zabka, AG ;
Mitchell, GS .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :25-35
[3]   Mammalian brainstem chemosensitive neurones:: linking them to respiration in vitro [J].
Ballantyne, D ;
Scheid, P .
JOURNAL OF PHYSIOLOGY-LONDON, 2000, 525 (03) :567-577
[4]   TASK-1 is a highly modulated pH-sensitive 'leak' K+ channel expressed in brainstem respiratory neurons [J].
Bayliss, DA ;
Talley, EM ;
Sirois, JE ;
Lei, QB .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :159-174
[5]   EFFECTS OF EXTRACELLULAR PH, PCO2 AND HCO3-ON INTRACELLULAR PH IN ISOLATED TYPE-I CELLS OF THE NEONATAL RAT CAROTID-BODY [J].
BUCKLER, KJ ;
VAUGHANJONES, RD ;
PEERS, C ;
LAGADICGOSSMANN, D ;
NYE, PCG .
JOURNAL OF PHYSIOLOGY-LONDON, 1991, 444 :703-721
[6]   WIDESPREAD SITES OF BRAIN-STEM VENTILATORY CHEMORECEPTORS [J].
COATES, EL ;
LI, AH ;
NATTIE, EE .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (01) :5-14
[7]   Cell-cell coupling in CO2/H+-excited neurons in brainstem slices [J].
Dean, JB ;
Kinkade, EA ;
Putnam, RW .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :83-100
[8]   Acid detection by taste receptor cells [J].
DeSimone, JA ;
Lyall, V ;
Heck, GL ;
Feldman, GM .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :231-245
[9]   Monoaminergic neurons, chemosensation and arousal [J].
Haxhiu, MA ;
Tolentino-Silva, F ;
Pete, G ;
Ke, P ;
Mack, SO .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :191-209
[10]   An alternative approach to the identification of respiratory central chemoreceptors in the brainstem [J].
Jiang, C ;
Xu, HX ;
Cui, NR ;
Wu, JP .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :141-157