Gas chromatographic-mass spectrometric analysis of urinary sugar and sugar alcohols during pregnancy

被引：25

作者：

Tetsuo, M

Zhang, CH

Matsumoto, H

Matsumoto, I

机构：

[1] Tetsuo Hosp, Nagasaki 8592502, Japan

[2] Nippon Red Cross Hosp, Kanazawa, Ishikawa, Japan

[3] Matsumoto Inst Life Sci, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B | 1999年 / 731卷 / 01期

关键词：

sugars; sugar alcohols;

D O I：

10.1016/S0378-4347(99)00209-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A refined and simplified method has been developed for the simultaneous analysis of urinary sugar and sugar alcohols after urease treatment by using capillary gas chromatography-mass spectrometry (GC-MS). Since carbohydrate metabolism during pregnancy is considered to be diabetogenic, our interest has been concentrated on understanding the mechanism of the metabolic deviation by assessing the glucose excursion and glucose fluxes. The present study suggests that changes of the levels of glucose, sorbitol, fructose, myo-inositol, and 1,5-anhydro-D-glucitol (1,5-AG) may reflect a mild alteration in carbohydrate metabolism that goes undetected by conventional diabetic indicators. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 120

页数：10

共 26 条

[1]

AKANUMA Y, 1988, DIABETOLOGIA, V31, P831

[2] DIRECT GAS CHROMATOGRAPHIC DETERMINATION OF POLYALCOHOLS IN BIOLOGICAL MEDIA [J].