Interaction of human papillomaviruses with the host immune system: A well evolved relationship

被引：134

作者：

Frazer, Ian H. ^{[1
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld 4102, Australia

来源：

VIROLOGY | 2009年 / 384卷 / 02期

关键词：

Papillomaviruses; Humoral immunity; Cellular immunity; Vaccines; CERVICAL INTRAEPITHELIAL NEOPLASIA; VIRUS-LIKE PARTICLES; T-CELL RESPONSES; MHC CLASS-I; DOWN-REGULATION; WHIM SYNDROME; L1; TYPE-16; E7; HUMAN-PAPILLOMAVIRUS-16;

D O I：

10.1016/j.virol.2008.10.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human papillomavirus (HPV) infections are generally long lasting, and a host immune response to infection is hard to detect. Nevertheless immunocompromised subjects control HPV infection less well than those with intact immunity. Immune responses are best documented for the papillomavirus groups that cause evident human disease, particularly those responsible for anogenital cancers and genital warts. Humoral immunity to the viral capsid has been shown sufficient for protection against infection, while innate and adaptive cell mediated immunity appears important for eventual elimination of HPV infection. However, molecular and cellular mechanisms responsible for protection from and clearance of HPV infection are not completely established. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：410 / 414

页数：5

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