WAVE signalling: from biochemistry to biology

被引：36

作者：

Soderling, SH ^{[1
]}

Scott, JD ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Vollum Inst, Howard Hughes Med Inst, Portland, OR 97239 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

actin remodelling; A-kinase anchoring protein (AKAP); cytoskeletal organization; kinase anchoring; Wiskott-Aldrich syndrome protein verprolin homologous protein(WAVE protein);

D O I：

10.1042/BST0340073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The small GTPases Rho, Rac and Cdc42 (cell-division cycle 42) function as molecular switches to modulate the actin cytoskeleton. They achieve this by modulating the activity of downstream cellular targets. One group of Rho GTPase effectors, WAVE (Wiskott-Aldrich syndrome protein verprolin homologous)-1, WAVE-2 and WAVE-3, function as scaffolds for actin-based signalling complexes. The present review highlights current knowledge regarding the biochemistry of the WAVE signalling complexes and their biological significance.

引用

页码：73 / 76

页数：4

共 34 条

[1] SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development [J].

Bear, JE ;

Rawls, JF ;

Saxe, CL .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1325-1335

[2] Abi activates WASP to promote sensory organ development [J].

Bogdan, S ;

Stephan, R ;

Löbke, C ;

Mertens, A ;

Klämbt, C .

NATURE CELL BIOLOGY, 2005, 7 (10) :977-U76

[3] Signaling pathways controlling cell polarity and chemotaxis [J].

Chung, CY ;

Funamoto, S ;

Firtel, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (09) :557-566

[4]

Dahl JP, 2003, J NEUROSCI, V23, P3343

[5] ABI-2, A NOVEL SH3-CONTAINING PROTEIN INTERACTS WITH THE C-ABL TYROSINE KINASE AND MODULATES C-ABL TRANSFORMING ACTIVITY [J].

DAI, ZH ;

PENDERGAST, AM .

GENES & DEVELOPMENT, 1995, 9 (21) :2569-2582

[6] Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels [J].

Echarri, A ;

Lai, MJ ;

Robinson, MR ;

Pendergast, AM .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (11) :4979-4993

[7] Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck [J].

Eden, S ;

Rohatgi, R ;

Podtelejnikov, AV ;

Mann, M ;

Kirschner, MW .

NATURE, 2002, 418 (6899) :790-793

[8] The novel Rho-GTPase activating gene MEGAP/srGAP3 has a putative role in severe mental retardation [J].

Endris, V ;

Wogatzky, B ;

Leimer, U ;

Bartsch, D ;

Zatyka, M ;

Latif, F ;

Maher, ER ;

Tariverdian, G ;

Kirsch, S ;

Karch, D ;

Rappold, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11754-11759

[9] Purification and architecture of the ubiquitous Wave complex [J].

Gautreau, A ;

Ho, HYH ;

Li, JX ;

Steen, H ;

Gygi, SP ;

Kirschner, MW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (13) :4379-4383

[10] Abi2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory [J].

Grove, M ;

Demyanenko, G ;

Echarri, A ;

Zipfel, PA ;

Quiroz, ME ;

Rodriguiz, RM ;

Playford, M ;

Martensen, SA ;

Robinson, MR ;

Wetsel, WC ;

Maness, PF ;

Pendergast, AM .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (24) :10905-10922

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