Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats

被引：16

作者：

Holtzman, D ^{[1
]}

Meyers, R ^{[1
]}

Khait, I ^{[1
]}

Jensen, F ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02138

来源：

EPILEPSY RESEARCH | 1997年 / 27卷 / 01期

关键词：

creatine kinase; phosphocreatine; ATP; brain; development; seizures;

D O I：

10.1016/S0920-1211(96)01019-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [P-31] nuclear magnetic resonance spectroscopy ([P-31]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats. The CK rate constants measured before seizures were three times higher in the older than in the younger rats. The rate constants increased 60% during seizures in the older rats but did not change or decreased in the younger. Small decreases in PCr were seen during seizures at both ages. A small decrease in ATP was seen at 7 days but not at 21 days. (C) 1997 Elsevier Science B.V.

引用

页码：7 / 11

页数：5

共 24 条

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