HIV-1 entry inhibitor entrances

被引：13

作者：

Kuhmann, SE ^{[1
]}

Moore, JP ^{[1
]}

机构：

[1] Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 03期

关键词：

D O I：

10.1016/j.tips.2004.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BMS-378806 is a newly described small-molecule inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. It acts by binding to the gp120 surface glycoprotein of the virus within, or very close to, the pocket normally occupied by the CD4 antigen, the primary cell-surface receptor protein of HIV-1. Consequently, BMS-378806 inhibits gp120-CD4 binding and the subsequent events of virus-cell attachment and fusion. Thus, BMS-378806 or a derivative could be highly suitable to treat HIV-1 infection, and perhaps also to prevent infection when used in combination with other inhibitors of HIV-1 entry.

引用

页码：117 / 120

页数：4

共 23 条

[1] The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication [J].

DeVreese, K ;

KoflerMongold, V ;

Leutgeb, C ;

Weber, V ;

Vermeire, K ;

Schacht, S ;

Anne, J ;

DeClercq, E ;

Datema, R ;

Werner, G .

JOURNAL OF VIROLOGY, 1996, 70 (02) :689-696

[2] Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions [J].

Guo, Q ;

Ho, HT ;

Dicker, I ;

Fan, L ;

Zhou, NN ;

Friborg, J ;

Wang, T ;

McAuliffe, BV ;

Wang, HGH ;

Rose, RE ;

Fang, H ;

Scarnati, HT ;

Langley, DR ;

Meanwell, NA ;

Abraham, R ;

Colonno, RJ ;

Lin, PF .

JOURNAL OF VIROLOGY, 2003, 77 (19) :10528-10536

[3]

Hammer Scott M., 2002, Top HIV Med, V10, P10

[4] Biological and genetic characterization of a human immunodeficiency virus strain resistant to CXCR4 antagonist t134 [J].

Kanbara, K ;

Sato, S ;

Tanuma, J ;

Tamamura, H ;

Gotoh, K ;

Yoshimori, M ;

Kanamoto, T ;

Kitano, M ;

Fujii, N ;

Nakashima, H .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (07) :615-622

[5] Novel therapies based on mechanisms of HIV-1 cell entry [J].

Kilby, JM ;

Eron, JJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (22) :2228-2238

[6]

KUHMANN SE, 2004, IN PRESS J VIROL

[7] Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody [J].

Kwong, PD ;

Wyatt, R ;

Robinson, J ;

Sweet, RW ;

Sodroski, J ;

Hendrickson, WA .

NATURE, 1998, 393 (6686) :648-659

[8] Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America [J].

Lalezari, JP ;

Henry, K ;

O'Hearn, M ;

Montaner, JSG ;

Piliero, PJ ;

Trottier, B ;

Walmsley, S ;

Cohen, C ;

Kuritzkes, DR ;

Eron, JJ ;

Chung, J ;

DeMasi, R ;

Donatacci, L ;

Drobnes, C ;

Delehanty, J ;

Salgo, M ;

Farthing, C ;

Graham, E ;

Packard, M ;

Ngo, L ;

Lederman, M ;

Buam, J ;

Pollard, R ;

Rauf, S ;

Silkowski, W ;

Thompson, M ;

Rucker, A ;

Harris, M ;

Larsen, G ;

Preseon, S ;

Cunningham, D ;

Guimaraes, D ;

Bertasso, A ;

Kinchelow, T ;

Myers, R ;

Phoenix, BCBP ;

Skolnik, PR ;

Adams, B ;

Leite, OHM ;

Oliveira, M ;

Lefebvre, E ;

Gomez, B ;

Foy, KB ;

Lampiris, H ;

Charles, S ;

Dobkin, J ;

Crawford, M ;

Slom, T ;

Murphy, R ;

Mikaitis, T .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (22) :2175-2185

[9] Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia [J].

Lazzarin, A ;

Clotet, B ;

Cooper, D ;

Reynes, J ;

Arasteh, K ;

Nelson, M ;

Katlama, C ;

Stellbrink, H ;

Delfraissy, J ;

Lange, J ;

Huson, L ;

DeMasi, R ;

Wat, C ;

Delehanty, J ;

Drobnes, C ;

Salgo, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (22) :2186-2195

[10] A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding [J].

Lin, PF ;

Blair, W ;

Wang, T ;

Spicer, T ;

Guo, Q ;

Zhou, NN ;

Gong, YF ;

Wang, HGH ;

Rose, R ;

Yamanaka, G ;

Robinson, B ;

Li, CB ;

Fridell, R ;

Deminie, C ;

Demers, G ;

Yang, Z ;

Zadjura, L ;

Meanwell, N ;

Colonno, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :11013-11018

← 1 2 3 →