Role of Apoptosis in disease

被引：508

作者：

Favaloro, B. ^{[1
,2
]}

Allocati, N. ^{[1
]}

Graziano, V. ^{[1
,2
]}

Di Ilio, C. ^{[1
,2
]}

De Laurenzi, V. ^{[1
,2
,3
]}

机构：

[1] Univ G dAnnunzio, Dipartimento Sci Biomed, I-66100 Chieti, Italy

[2] Fdn G dAnnunzio, Ctr Studi Invecchiamento, CeSI, I-66100 Chieti, Italy

[3] Univ Salerno, BIOUNIVERSA Srl, Fisciano, SA, Italy

来源：

AGING-US | 2012年 / 4卷 / 05期

关键词：

cell death; caspases; apoptosis; cancer; aging; diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; HEPATITIS-B-VIRUS; NF-KAPPA-B; ACUTE LYMPHOBLASTIC-LEUKEMIA; BCL2 PROMOTER POLYMORPHISM; BREAST-CANCER PATIENTS; ISCHEMIC BRAIN-INJURY; CELL LUNG-CANCER; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE;

D O I：

10.18632/aging.100459

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.

引用

页码：330 / 349

页数：20

共 208 条

[1]

Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents [J].

Abou-Kandil, Ammar ;

Chamias, Rachel ;

Huleihel, Mahmoud ;

Godbey, W. T. ;

Aboud, Mordechai .

CELL CYCLE, 2011, 10 (19) :3337-3345

[2]

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia [J].

Adibhatla, RM ;

Hatcher, JF .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (03) :376-387

[3]

Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach [J].

Ai, X. ;

Butts, B. ;

Vora, K. ;

Li, W. ;

Tache-Talmadge, C. ;

Fridman, A. ;

Mehmet, H. .

CELL DEATH & DISEASE, 2011, 2 :e205-e205

[4]

Suicide watch: how cytomegalovirus interferes with the cell-death pathways of infected cells [J].

Andoniou, C. E. .

TISSUE ANTIGENS, 2010, 76 (01) :1-8

[5]

Role of the Hepatitis B virus proteins in pro- and anti-apoptotic processes [J].

Assrir, Nadine ;

Soussan, Patrick ;

Kremsdorf, Dina ;

Rossignol, Jean-Michel .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2010, 15 :12-24

[6]

The AA genotype of the regulatory BCL2 promoter polymorphism (-938C⟩A) is associated with a favorable outcome in lymph node-negative invasive breast cancer patients [J].

Bachmann, Hagen S. ;

Otterbach, Friedrich ;

Callies, Rainer ;

Nueckel, Holger ;

Bau, Maja ;

Schmid, Kurt W. ;

Siffert, Winfried ;

Kimmig, Rainer .

CLINICAL CANCER RESEARCH, 2007, 13 (19) :5790-5797

[7]

Mitochondrial involvement in amyotrophic lateral sclerosis - Trigger or target? [J].

Bacman, SR ;

Bradley, WG ;

Moraes, CT .

MOLECULAR NEUROBIOLOGY, 2006, 33 (02) :113-131

[8]

Neurodegenerative processes in Huntington's disease [J].

Bano, D. ;

Zanetti, F. ;

Mende, Y. ;

Nicotera, P. .

CELL DEATH & DISEASE, 2011, 2 :e228-e228

[9]

Banwait S, 2008, J ALZHEIMERS DIS, V13, P1

[10]

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease [J].

Barcia, C. ;

Ros, C. M. ;

Annese, V. ;

Gomez, A. ;

Ros-Bernal, F. ;

Aguado-Yera, D. ;

Martinez-Pagan, M. E. ;

de Pablos, V. ;

Fernandez-Villalba, E. ;

Herrero, M. T. .

CELL DEATH & DISEASE, 2011, 2 :e142-e142

← 1 2 3 4 5 6 7 8 9 10 →