Synthesis, characterization, and antitumor activity of a series of novel cisplatin analogs with cis-1,4-diaminocyclohexane as nonleaving amine group

被引：48

作者：

Shamsuddin, S ^{[1
]}

Takahashi, I ^{[1
]}

Siddik, ZH ^{[1
]}

Khokhar, AR ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CLIN INVEST,HOUSTON,TX 77030

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1996年 / 61卷 / 04期

关键词：

D O I：

10.1016/0162-0134(95)00084-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel platinum(II) complexes of the type Pt-II(cis-1,4-DACH)X (where cis-1,4-DACH = cis-1,4-diaminocyclohexane and X = dichloro, sulfate, oxalato, malonato, methylmalonato, tartronato, or 1,1-cyclobutanedicarboxylato [CBDCA) ligand and novel platinum(IV) complexes of the types Pt-IV(cis-1,4-DACH)trans(Y)(2)Cl-2 (where Y = chloro, hydroxo, acetato, propionato, or butyrato ligand) and Pt-IV(cis-1,4-DACH)trans(Cl)(2)(X) (where X = oxalato or CBDCA ligand) were synthesized and characterized by elemental analysis, infrared, and Pt-195 NMR spectroscopic techniques. Platinum complexes had good in vitro cytotoxic activity against murine leukemia L1210/0 (IC50 = 0.0032 - 1.60 mu M) and human ovarian A2780 (IC50 = 0.045 - 0.430 mu M) cell lines.

引用

页码：291 / 301

页数：11

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