One hit, two outcomes for VHL-mediated tumorigenesis

被引：6

作者：

Behrens, Juergen ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, D-91341 Erlangen, Germany

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 10期

关键词：

D O I：

10.1038/ncb1008-1127

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The tumour suppressor vHL is known to suppress hypoxia-induced gene expression by degrading HIF family transcription factors. evidence that vHL also targets the oncoprotein beta-catenin for degradation highlights a new road to transformation by loss of vHL.

引用

页码：1127 / 1128

页数：3

共 15 条

[1]

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL [J].

Chitalia, Vipul C. ;

Foy, Rebecca L. ;

Bachschmid, Markus M. ;

Zeng, Liling ;

Panchenko, Maria V. ;

Zhou, Mina I. ;

Bharti, Ajit ;

Seldin, David C. ;

Lecker, Stewart H. ;

Dominguez, Isabel ;

Cohen, Herbert T. .

NATURE CELL BIOLOGY, 2008, 10 (10) :1208-1216

[2]

Wnt/β-catenin signaling in development and disease [J].

Clevers, Hans .

CELL, 2006, 127 (03) :469-480

[3]

Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis [J].

Giles, R. H. ;

Lolkema, M. P. ;

Snijckers, C. M. ;

Belderbos, M. ;

van der Groep, P. ;

Mans, D. A. ;

van Beest, M. ;

van Noort, M. ;

Goldschmeding, R. ;

van Diest, P. J. ;

Clevers, H. ;

Voest, E. E. .

ONCOGENE, 2006, 25 (21) :3065-3070

[4]

The VHL tumor suppressor in development and disease: Functional studies in mice by conditional gene targeting [J].

Haase, VH .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (4-5) :564-574

[5]

Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia [J].

Kaidi, Abderrahmane ;

Williams, Ann Caroline ;

Paraskeva, Christos .

NATURE CELL BIOLOGY, 2007, 9 (02) :210-U113

[6]

Role of VHL gene mutation in human cancer [J].

Kim, WY ;

Kaelin, WG .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (24) :4991-5004

[7]

The !von Hippel-Lindau tumor suppressor gene product represses oncogenic β-catenin signaling in renal carcinoma cells [J].

Peruzzi, Benedetta ;

Athauda, Gagani ;

Bottaro, Donald P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (39) :14531-14536

[8]

Polakis P, 2000, GENE DEV, V14, P1837

[9]

Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium [J].

Qian, CN ;

Knol, J ;

Igarashi, P ;

Lin, FM ;

Zylstra, U ;

Teh, BT ;

Williams, BO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (05) :3938-3945

[10]

Rend cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor [J].

Rankin, EB ;

Tomaszewski, JE ;

Haase, VH .

CANCER RESEARCH, 2006, 66 (05) :2576-2583

← 1 2 →