Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives.

被引：10

作者：

Bedeschi, A

Zarini, F

Cabri, W

Candiani, I

Penco, S

Capolongo, L

Ciomei, M

Farao, M

Grandi, M

机构：

[1] Pharmacia, Oncology-Immunology, 23 20014 Nerviano (MI), Via Giovanni XXIII

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00083-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.

引用

页码：671 / 674

页数：4

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