In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine

被引：58

作者：

Ajaiyeoba, EO ^{[1
]}

Abiodun, OO

Falade, MO

Ogbole, NO

Ashidi, JS

Happi, CT

Akinboye, DO

机构：

[1] Univ Ibadan, Fac Pharm, Dept Pharmacognosy, Ibadan, Nigeria

[2] Univ Ibadan, Dept Pharmacol, Ibadan, Nigeria

[3] Univ Ibadan, Dept Zool, Ibadan, Nigeria

[4] Univ Ibadan, Malaria Res Grp, Inst Adv Med Res & Training, Ibadan, Nigeria

来源：

PHYTOMEDICINE | 2006年 / 13卷 / 04期

关键词：

cytotoxicity; plants; Nigeria; antimalarial ethnomedicine;

D O I：

10.1016/j.phymed.2005.01.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Twenty plants identified and selected from Southwest and Middle belt Nigerian antimalarial ethnopharmacology were evaluated for in vitro cytotoxicity using the brine shrimp lethality assay. The methanol extracts of 20 plant samples from 11 plant families were subjected to the assay. Of the studied plants, Lippia multiflora and Morinda lucida bark were found to be cytotoxic, with LC50 values of 1.1 and 2.6 mu g/ml, respectively. The least toxic plant extract was Bridelia micrantha (LC50 value >9.0 X 10(6) mu g/ml). Most of the plants were found to be relatively non-toxic. (c) 2005 Elsevier GrnbH. All rights reserved.

引用

页码：295 / 298

页数：4

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