Soluble CD40 ligand as a biomarker for storage-related preanalytic variations of human serum

被引：28

作者：

Lengelle, Juliette ^{[1
]}

Panopoulos, Evangelos ^{[1
]}

Betsou, Fotini ^{[1
]}

机构：

[1] CHU Amiens, F-80480 Salouel, France

来源：

CYTOKINE | 2008年 / 44卷 / 02期

关键词：

Biobank; Serum; Quality control; Preanalytic variation; Cytokines;

D O I：

10.1016/j.cyto.2008.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are Currently no appropriate and sensitive biomarkers available to assess preanalytic variations in human biological fluids stored in biobanks. We identified soluble CD40 ligand (sCD40L) as the first ubiquitous biomarker to show an on-off response in serum exposed to moderate or elevated room temperature conditions. We used immunoenzyme assays to monitor the sCD40L response after 12 h storage at 37 degrees C or 48 h at 20 degrees C. Our findings show that prolonged storage of serum samples at elevated room temperature can be determined by the absence of detectable sCD40L (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：275 / 282

页数：8

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