Enantiopure Peptide-Functionalized Metal-Organic Frameworks

被引：174

作者：

Bonnefoy, Jonathan ^{[1
,2
]}

Legrand, Alexandre ^{[1
]}

Quadrelli, Elsje Alessandra ^{[2
]}

Canivet, Jerome ^{[1
]}

Farrusseng, David ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, IRCELYON, UMR 5256, F-69626 Villeurbanne, France

[2] Univ Lyon 1, CPE Lyon, CNRS, C2P2,UMR 5265, F-69616 Villeurbanne, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 29期

关键词：

AMINO-ACID; ASYMMETRIC CATALYSIS; DERIVATIVES; ADSORPTION; REDUCTION; TOPOLOGY; PYBROP; MIL-68; ROUTE; SALTS;

D O I：

10.1021/jacs.5b05327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present herein the first example of metal-organic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH2, In-MIL-68-NH2, and Zr-UiO-66-NH2 were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction.

引用

页码：9409 / 9416

页数：8

共 101 条

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