Biodegradable dextran-polylactide hydrogel networks: Their swelling, morphology and the controlled release of indomethacin

被引:55
作者
Zhang, YL
Chu, CC [1 ]
机构
[1] Cornell Univ, Dept Text, Fiber & Polymer Sci Program, Ithaca, NY 14853 USA
[2] Cornell Univ, Apparel & Biomed Engn Program, Ithaca, NY 14853 USA
来源
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 2002年 / 59卷 / 02期
关键词
dextran; polylactide; polymer network; hydrogel; swelling; biodegradation; indomethacin; photocrosslinking; drug release; morphology;
D O I
10.1002/jbm.1248
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Biodegradable polymer hydrogel networks based on hydrophilic dextran derivative of allyl isocyanate (dex-AI) and hydrophobic poly (D,L) lactide diacrylate macromer (PDLLAM) were synthesized, and their swelling and morphological properties were studied. During a 2-day incubation, the higher the PDLLAM composition in the hydrogel, the slower the swelling as well as the lower the extent of swelling were. A 3D porous network structure was observed by scanning electron microscope. The rate of formation of this 3D porous network structure depended on the hydrophilicity of the components, their composition ratio, and the degradation time. The highly hydrophilic dex-AI component facilitated the formation of this 3D porous network structure at an earlier immersion period, while the degradability,of the PDLLAM component would make this 3D porous network structure more open at a later immersion period. Indomethacin, a low molecular weight and moderately hydrophobic drug, was incorporated into the hydrogels for the release study in pH 7.4 phosphate buffer solution at 37 degreesC. The release kinetics suggested, as the PDLLAM composition increased, the indomethacin diffusion coefficient (D) and release half life time (t(1/2)) decreased, while the release index n increased. The controlled release mechanism was determined by the combination of three factors: the rate and degree of formation of swelling-induced 3D porous structure in the hydrogel, the hydrolytic degradation of PDLLAM components, and the hydrophobic interaction between PDLLAM and IDM. (C) 2001 John Wiley & Sons, Inc.
引用
收藏
页码:318 / 328
页数:11
相关论文
共 44 条
[1]   Novel pH-sensitive hydrogels with adjustable swelling kinetics [J].
Akala, EO ;
Kopecková, P ;
Kopecek, J .
BIOMATERIALS, 1998, 19 (11-12) :1037-1047
[2]   Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels [J].
Allcock, HR ;
Ambrosio, AMA .
BIOMATERIALS, 1996, 17 (23) :2295-2302
[3]  
Aronhime M., 1994, Clinical Materials, V15, P161, DOI 10.1016/0267-6605(94)90079-5
[4]   Crosslinked dextran - a new capsule material for colon targeting of drugs [J].
Brondsted, H ;
Andersen, C ;
Hovgaard, L .
JOURNAL OF CONTROLLED RELEASE, 1998, 53 (1-3) :7-13
[5]  
Cadée JA, 2000, J BIOMED MATER RES, V50, P397
[6]   The control of protein release from poly(DL-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method [J].
Coombes, AGA ;
Yeh, MK ;
Lavelle, EC ;
Davis, SS .
JOURNAL OF CONTROLLED RELEASE, 1998, 52 (03) :311-320
[7]   KINETICS OF DRUG-RELEASE FROM HYDROPHOBIC POLYBASIC GELS - EFFECT OF BUFFER ACIDITY [J].
CORNEJOBRAVO, JM ;
ARIASSANCHEZ, V ;
ALVAREZANGUIANO, A ;
SIEGEL, RA .
JOURNAL OF CONTROLLED RELEASE, 1995, 33 (02) :223-229
[8]  
Ende MTA, 1997, J CONTROL RELEASE, V48, P47
[9]   Production and characterization of biodegradable microparticles for the controlled delivery of proteinase inhibitors [J].
Esposito, E ;
Cortesi, R ;
Bortolotti, F ;
Menegatti, E ;
Nastruzzi, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 129 (1-2) :263-273
[10]   Investigation of the mechanisms governing the release of levamisole from poly-lactide-co-glycolide delivery systems [J].
Fitzgerald, JF ;
Corrigan, OI .
JOURNAL OF CONTROLLED RELEASE, 1996, 42 (02) :125-132